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Literature summary extracted from

  • Davis, A.E.; Mejia, P.; Lu, F.
    Biological activities of C1 inhibitor (2008), Mol. Immunol., 45, 4057-4063.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.21.41 medicine anti-inflammatory functions are exerted via inhibition of complement system proteases (C1r, C1s, MASP2) and the plasma kallikrein-kinin system proteases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.38 alpha2-Macroglobulin
-
 Homo sapiens
3.4.21.38 C1 inhibitor
-
 Homo sapiens
3.4.21.41 C1 inhibitor during complex formation, C1 inhibitor dissociates C1r and C1s from the activated C1 macromolecule, a process that is determined primarily by the interaction with C1r Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-
3.4.21.41 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 factor XI + H2O
-
 Homo sapiens factor XIa + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 factor XII
-
 Homo sapiens
3.4.21.41 C1r
-
 Homo sapiens